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However, the exact same focus of Acquire but not other CB1R agonists, raises intracellular Ca2+ focus by means of Gq/eleven protein in transfected HEK-293 cells and cultured hippocampal neurons with endogenous receptor expression [ninety three]. Moreover, in mice hippocampal slices, CB1R expressed in astrocytes is coupled to Gq/11, boosts intracell
=nine). This is due to THC-induced dopamine release during the striatum seems being of a lessen magnitude than that a result of other medicines including amphetamine and methylphenidate60, coupled with problems in imaging dopamine adjustments that are comparatively small61.1999; Hindmarch et al. 2000). Users have reactions’ towards the pharmacolo